N,N-Dimethylglycine or DMG is a natural amino acid that plays a critical role in supporting health, vitality and wellness in the body*. Our bodies produce this vital nutrient naturally, but in a world of high stress and heavy demand we don't produce adequate amounts of DMG.
By taking supplemental DMG you provide your body with the support to the stresses of today's world.
By taking supplemental DMG you provide your body with the support to the stresses of today's world.
D&d Beyond
How DMG helps the body to work better*:
Athletic Performance - DMG supports oxygen utilization, decreases lactic acid buildup, encourages greater endurance and stamina as well as better muscle recovery after strenuous exercise*.
Cardiovascular Health - DMG supports normal cholesterol and triglyceride levels, improves circulation, supports healthy blood pressure and homocysteine levels and helps combat hypoxia (low oxygen levels)*.
Immune System Support - DMG supports the immune system by promoting B-cell, T-cell and macrophage activity. It can help support the body's resistance to infections*.
Liver Function - DMG acts as a methyl donor, detoxifier, and supports Glutathione and SAMe production. It defends the liver and the rest of the body from toxins*.
Neurological Functions - DMG provides important building blocks for the synthesis of neurotransmitters and hormones. It supports energy production for the brain and may be beneficial for those affected by seizures*.
Anti-Stress - DMG helps the body cope with physical, emotional and metabolic stress by improving oxygen utilization and supporting the immune system when being challenged*.
Cardiovascular Health - DMG supports normal cholesterol and triglyceride levels, improves circulation, supports healthy blood pressure and homocysteine levels and helps combat hypoxia (low oxygen levels)*.
Immune System Support - DMG supports the immune system by promoting B-cell, T-cell and macrophage activity. It can help support the body's resistance to infections*.
Liver Function - DMG acts as a methyl donor, detoxifier, and supports Glutathione and SAMe production. It defends the liver and the rest of the body from toxins*.
Neurological Functions - DMG provides important building blocks for the synthesis of neurotransmitters and hormones. It supports energy production for the brain and may be beneficial for those affected by seizures*.
Anti-Stress - DMG helps the body cope with physical, emotional and metabolic stress by improving oxygen utilization and supporting the immune system when being challenged*.
Names | |
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IUPAC name | |
Other names N,N-Dimethylglycine | |
Identifiers | |
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3DMet | |
1700261 | |
ChEBI | |
ChemSpider |
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DrugBank | |
ECHA InfoCard | 100.012.971 |
EC Number |
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82215 | |
KEGG |
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MeSH | dimethylglycine |
RTECS number | |
CompTox Dashboard(EPA) | |
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Properties | |
C4H9NO2 | |
Molar mass | 103.121 g·mol−1 |
Appearance | White crystals |
Odor | Odourless |
Density | 1.069 g/mL |
Melting point | 178 to 182 °C (352 to 360 °F; 451 to 455 K) |
Boiling point | 175.2 °C (347.4 °F; 448.3 K) |
Hazards | |
GHS pictograms | |
GHS Signal word | Warning |
H302 | |
Lethal dose or concentration (LD, LC): | |
>650 mg kg−1(oral, rat) | |
Related compounds | |
Related alkanoic acids | |
Dimethylacetamide | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references |
Acid (vial) As an action, you can splash the contents of this vial onto a creature within 5 feet of you or throw the vial up to 20 feet, shattering it on impact. In either case, make a ranged attack against a creature or object, treating the acid as an improvised weapon. On a hit, the target takes 2d6 acid damage. Certain creatures also have favored types of damage to inflict (Black Dragons deal primarily acid damage, Demons deal mainly necrotic damage, etc.). Not all attacks have typed damage. Acid: Corrosive liquid. Cold: Ice crystals, arctic air, or frigid liquid. Fire: Explosive bursts, fiery rays, or simple ignition.
Dimethylglycine (DMG) is a derivative of the amino acidglycine with the structural formula (CH3)2NCH2COOH. It can be found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline.
As an action, you can splash the contents of this vial onto a creature within 5 feet of you or throw the vial up to 20 feet, shattering it on impact. In either case, make a ranged attack against a creature or object, treating the acid as an improvised weapon. On a hit, the target takes 2d6 acid damage. Weight: 1 lb. You conjure a bolt of solidified acid that melts inside your target. It propels itself at a creature or object within range. Make a ranged spell attack against the target. On a hit, the target takes 1d6 piercing damage. If the target is a creature, it must make a Constitution saving throw or take an additional 1d6 Acid damage. As an action, you can splash the contents of this vial onto a creature within 5 feet of you or throw the vial up to 20 feet, shattering it on impact. In either case, make a ranged Attack against a creature or object, treating the acid as an Improvised Weapon. On a hit, the target takes 2d6 acid damage. Braunwald celebrates the moment when he finally gets his horse in our 453rd DDO Screenshot of the Week!
When DMG was first discovered, it was referred to as Vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects and it is synthesized by the human body in the citric acid (or Krebs) cycle meaning it does not meet the definition of a vitamin.
Uses[edit]
Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease.[2] There is no evidence that dimethylglycine is effective for treating mitochondrial disease.[3] Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.[4][5]
Biological activity[edit]
Dimethylglycine has been found to act as an agonist of the glycine site of the NMDA receptor.[6]
Preparation[edit]
This compound is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may have been obtained by neutralization of the acid salt, which has been performed with silver oxide.[7]
- H2NCH2COOH + 2 CH2O + 2 HCOOH → (CH3)2NCH2COOH + 2 CO2 + 2 H2O
References[edit]
- ^'dimethylglycine - Compound Summary'. PubChem Compound. USA: National Center for Biotechnology Information. 16 September 2004. Identification. Retrieved 24 April 2012.
- ^'Dimethylglycine'. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. December 8, 2009.
- ^Pfeffer, Gerald; Majamaa, Kari; Turnbull, Douglass M.; Thorburn, David; Chinnery, Patrick F. (2012-04-18). 'Treatment for mitochondrial disorders'. The Cochrane Database of Systematic Reviews (4): CD004426. doi:10.1002/14651858.CD004426.pub3. ISSN1469-493X. PMID22513923.
- ^Bolman WM, Richmond JA (June 1999). 'A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder'. Journal of Autism and Developmental Disorders. 29 (3): 191–4. doi:10.1023/A:1023023820671. PMID10425581.
- ^Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). 'Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder'. Journal of Child Neurology. 16 (3): 169–73. doi:10.1177/088307380101600303. PMID11305684.
- ^Lin, Jen-Cheng; Chan, Ming-Huan; Lee, Mei-Yi; Chen, Yi-Chyan; Chen, Hwei-Hsien (2016). 'N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice'. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 71: 7–13. doi:10.1016/j.pnpbp.2016.06.002. ISSN0278-5846. PMID27296677.
- ^Clarke, H. T.; Gillespie, H. B.; Weisshaus, S. Z. (1933). 'The Action of Formaldehyde on Amines and Amino Acids'. Journal of the American Chemical Society. 55 (11): 4571. doi:10.1021/ja01338a041.
Acid Damage Dnd
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